She began her career in 2001 by acting in a small role as the heroine’s friend in the film Theerthadanam. Though it was a small role, Rachana considers it as a gratifying experience to have begun her career through a film scripted by M. T. Vasudevan Nair. After her studies, she joined radio as an RJ, at Radio Mango, Thrissur, where a producer spotted her and cast her in Marimayam. Rachana had only intended to act in a single episode of Marimayam, but was taken aback by the overwhelming response her character got, and decided to continue.
She hosted a comedy show Comedy Festival in Mazhavil Manorama. She has also acted in few advertisements and served as judge in the reality show Comedy Express on Asianet. She participated in the reality show Star Challenge on Flowers TV.